Profile
- MD, Mmed (pediatrics) University of Nairobi, Kenya 1989-1991
- Registered as medical practitioner with Kenya Medical Practitioners and Dentistry Board (A2577) 1986
- Worked in the Public health service for 33 years as medical officer and consultant pediatrician 1985-2018
- Received Kenya Medical Association prize for the best final year student Mentor to health workers especially junior doctors, students in high school and medical Universities/ Colleges 1993-2023
- Won Opus Prize a humanitarian award for faith-based entrepreneurship, Marquette University, Milwaukee, Wisconsin, USA
- CEO Jaramogi Teaching and Referral Hospital (JOOTRH), western Kenya largest public teaching and referral hospital 2007-2018
- Lecturer at Uzima University – Medical School – 2018
- Local Safety Monitor for various studies-KEMRI
- Senior Lecturer/HoD Department of Paediatric and Child Health Uzima University – 2020 -present
- Local Safety Monitor for KENYA LRLS KEMRI Protocol# 443(Malaria vaccine trial) 2022-present
- Inspired Leadership Initiative Program Fellow, University of Notre Dame, Indiana, USA 2019 August –2020 May
- Peer-reviewed publications
1: Mbori-Ngacha DA, Otieno JA, Njeru EK, Onyango FE. Prevalence of persistentdiarrhoea in children aged 3-36 months at the Kenyatta National Hospital,Nairobi, Kenya. East Afr Med J. 1995 Nov;72(11):711-4. PMID: 8904061.2: Ayisi JG, van Eijk AM, ter Kuile FO, Kolczak MS, Otieno JA, Misore AO, KagerPA, Steketee RW, Nahlen BL. Risk factors for HIV infection among asymptomaticpregnant women attending an antenatal clinic in western Kenya. Int J STD AIDS.2000 Jun;11(6):393-401. doi: 10.1258/0956462001916119. PMID: 10872913.3: van Eijk AM, Ayisi JG, ter Kuile FO, Misore A, Otieno JA, Kolczak MS, KagerPA, Steketee RW, Nahlen BL. Human immunodeficiency virus seropositivity andmalaria as risk factors for third-trimester anemia in asymptomatic pregnantwomen in western Kenya. Am J Trop Med Hyg. 2001 Nov;65(5):623-30. doi:10.4269/ajtmh.2001.65.623. PMID: 11716125.4: van Eijk AM, Ayisi JG, Ter Kuile FO, Misore AO, Otieno JA, Kolczak MS, KagerPA, Steketee RW, Nahlen BL. Malaria and human immunodeficiency virus infectionas risk factors for anemia in infants in Kisumu, western Kenya. Am J Trop MedHyg. 2002 Jul;67(1):44-53. doi: 10.4269/ajtmh.2002.67.44. PMID: 12363063.5: van Eijk AM, Ayisi JG, ter Kuile FO, Misore AO, Otieno JA, Rosen DH, KagerPA, Steketee RW, Nahlen BL. Risk factors for malaria in pregnancy in an urbanand peri-urban population in western Kenya. Trans R Soc Trop Med Hyg. 2002 Nov-Dec;96(6):586-92. doi: 10.1016/s0035-9203(02)90319-6. PMID: 12625128.6: Ayisi JG, van Eijk AM, ter Kuile FO, Kolczak MS, Otieno JA, Misore AO, KagerPA, Steketee RW, Nahlen BL. The effect of dual infection with HIV and malaria onpregnancy outcome in western Kenya. AIDS. 2003 Mar 7;17(4):585-94. doi:10.1097/00002030-200303070-00014. PMID: 12598779.7: van Eijk AM, Ayisi JG, ter Kuile FO, Misore AO, Otieno JA, Rosen DH, KagerPA, Steketee RW, Nahlen BL. HIV increases the risk of malaria in women of allgravidities in Kisumu, Kenya. AIDS. 2003 Mar 7;17(4):595-603. doi:10.1097/00002030-200303070-00015. PMID: 12598780.8: van Eijk AM, De Cock KM, Ayisi JG, Rosen DH, Otieno JA, Nahlen BL, Steketee RW. Pregnancy interval and delivery outcome among HIV-seropositive and HIV-seronegative women in Kisumu, Kenya. Trop Med Int Health. 2004 Jan;9(1):15-24.doi: 10.1046/j.1365-3156.2003.01165.x. PMID: 14728603.9: Van Eijk AM, Ayisi JG, ter Kuile FO, Otieno JA, Misore AO, Odondi JO, Rosen DH, Kager PA, Steketee RW, Nahlen BL. Effectiveness of intermittent preventivetreatment with sulphadoxine-pyrimethamine for control of malaria in pregnancy inwestern Kenya: a hospital-based study. Trop Med Int Health. 2004Mar;9(3):351-60. doi: 10.1111/j.1365-3156.2004.01196.x. PMID: 14996364.10: Ayisi JG, van Eijk AM, Newman RD, ter Kuile FO, Shi YP, Yang C, Kolczak MS,Otieno JA, Misore AO, Kager PA, Lal RB, Steketee RW, Nahlen BL. Maternal malariaand perinatal HIV transmission, western Kenya. Emerg Infect Dis. 2004Apr;10(4):643-52. doi:10.3201/eid1004.030303. PMID: 15200854; PMCID:PMC3323077.
11: van Eijk AM, Ayisi JG, ter Kuile FO, Slutsker L, Otieno JA, Misore AO,
Odondi JO, Rosen DH, Kager PA, Steketee RW, Nahlen BL. Implementation ofintermittent preventive treatment with sulphadoxine-pyrimethamine for control ofmalaria in pregnancy in Kisumu, western Kenya. Trop Med Int Health. 2004May;9(5):630-7. doi: 10.1111/j.1365-3156.2004.01242.x. PMID: 15117309.12: Bonner PC, Zhou Z, Mirel LB, Ayisi JG, Shi YP, van Eijk AM, Otieno JA,Nahlen BL, Steketee RW, Udhayakumar V. Placental malaria diminishes developmentof antibody responses to Plasmodium falciparum epitopes in infants residing in an area of western Kenya where P. falciparum is endemic. Clin Diagn Lab Immunol.2005 Mar;12(3):375-9. doi: 10.1128/CDLI.12.3.375-379.2005. PMID: 15753250;
PMCID: PMC1065200.13: van’t Hoog AH, Mbori-Ngacha DA, Marum LH, Otieno JA, Misore AO, Nganga LW,Decock KM. Preventing mother-to-child transmission of HIV in Western Kenya:operational issues. J Acquir Immune Defic Syndr. 2005 Nov 1;40(3):344-9. doi:10.1097/01.qai.0000160712.86580.ff. PMID: 16249710.
14: Brouwer KC, Mirel LB, Yang C, Lal RB, Kolczak MS, Van Eijk AM, Ayisi J,Otieno JA, Nahlen BL, Steketee R, Shi YP, Lal AA. Subclinical Plasmodiumfalciparum infection and HIV-1 viral load. Emerg Infect Dis. 2007Feb;13(2):351-3. doi: 10.3201/eid1302.060573. PMID: 17479917; PMCID: PMC2725849.
15: van Eijk AM, Ayisi JG, Slutsker L, Ter Kuile FO, Rosen DH, Otieno JA, ShiYP, Kager PA, Steketee RW, Nahlen BL. Effect of haematinic supplementation andmalaria prevention on maternal anaemia and malaria in western Kenya. Trop MedInt Health. 2007 Mar;12(3):342-52. doi: 10.1111/j.1365-3156.2006.01787.x. PMID:17313505.
16: van Eijk AM, Ayisi JG, Ter Kuile FO, Slutsker L, Shi YP, Udhayakumar V,Otieno JA, Kager PA, Lal RB, Steketee RW, Nahlen BL. HIV, malaria, and infant anemia as risk factors for postneonatal infant mortality among HIV-seropositive women in Kisumu, Kenya. J Infect Dis. 2007 Jul 1;196(1):30-7. doi:10.1086/518441. Epub 2007 May 16. PMID: 17538880.
17: Ned RM, Price AE, Crawford SB, Ayisi JG, van Eijk AM, Otieno JA, Nahlen BL,Steketee RW, Slutsker L, Shi YP, Lanar DE, Udhayakumar V. Effect of placental malaria and HIV infection on the antibody responses to Plasmodium falciparum in infants. J Infect Dis. 2008 Dec 1;198(11):1609-19. doi: 10.1086/593066. PMID:18928377.
18: Moormann AM, Heller KN, Chelimo K, Embury P, Ploutz-Snyder R, Otieno JA,Oduor M, Münz C, Rochford R. Children with endemic Burkitt lymphoma are deficient in EBNA1-specific IFN-gamma T cell responses. Int J Cancer. 2009 Apr 1;124(7):1721-6. doi: 10.1002/ijc.24014. PMID: 19089927; PMCID: PMC2708320.
19: Asito AS, Piriou E, Odada PS, Fiore N, Middeldorp JM, Long C, Dutta S, Lanar DE, Jura WG, Ouma C, Otieno JA, Moormann AM, Rochford R. Elevated anti-Zta IgG levels and EBV viral load are associated with site of tumor presentation in endemic Burkitt’s lymphoma patients: a case control study. Infect Agent Cancer. 2010 Jul 28;5:13. doi: 10.1186/1750-9378-5-13. PMID: 20667138; PMCID:PMC2923120.
20: Geng EH, Hunt PW, Diero LO, Kimaiyo S, Somi GR, Okong P, Bangsberg DR, BwanaMB, Cohen CR, Otieno JA, Wabwire D, Elul B, Nash D, Easterbrook PJ, Braitstein P, Musick BS, Martin JN, Yiannoutsos CT, Wools-Kaloustian K. Trends in the clinical characteristics of HIV-infected patients initiating antiretroviral
therapy in Kenya, Uganda and Tanzania between 2002 and 2009. J Int AIDS Soc. 2011 Sep 28;14:46. doi: 10.1186/1758-2652-14-46. PMID: 21955541; PMCID:PMC3204275.21: Buckle GC, Collins JP, Sumba PO, Nakalema B, Omenah D, Stiffler K, Casper C,Otieno JA, Orem J, Moormann AM. Factors influencing time to diagnosis and initiation of treatment of endemic Burkitt Lymphoma among children in Uganda and western Kenya: a cross-sectional survey. Infect Agent Cancer. 2013 Sep 30;8(1):36. doi: 10.1186/1750-9378-8-36. PMID: 24079452; PMCID: PMC3849966.
22: Buckle G, Maranda L, Skiles J, Ong’echa JM, Foley J, Epstein M, Vik TA, Schroeder A, Lemberger J, Rosmarin A, Remick SC, Bailey JA, Vulule J, Otieno JA, Moormann AM. Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study. Int J Cancer. 2016 Sep 15;139(6):1231-40. doi: 10.1002/ijc.30170. Epub 2016 May 18. PMID: 27136063; PMCID: PMC5489240.
23: Parsons E, Otieno JA, Ong’echa JM, Nixon CE, Vulule J, Münz C, Stewart VA,Moormann AM. Regulatory T Cells in Endemic Burkitt Lymphoma Patients Are Associated with Poor Outcomes: A Prospective, Longitudinal Study. PLoS One. 2016 Dec 29;11(12):e0167841. doi: 10.1371/journal.pone.0167841. PMID: 28033393; PMCID: PMC5199096.
24: Kaymaz Y, Oduor CI, Yu H, Otieno JA, Ong’echa JM, Moormann AM, Bailey JA. Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences. Mol Cancer Res. 2017 May;15(5):563-576. doi: 10.1158/1541-7786.MCR-16-0305. PMID: 28465297; PMCID: PMC5471630.
25: Oduor CI, Kaymaz Y, Chelimo K, Otieno JA, Ong’echa JM, Moormann AM, Bailey JA. Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma. BMC Cancer. 2017 Nov 13;17(1):761. doi:10.1186/s12885-017-3711-9. PMID: 29132323; PMCID: PMC5683570.
26: Forconi CS, Cosgrove CP, Saikumar-Lakshmi P, Nixon CE, Foley J, Ong’echa JM,Otieno JA, Alter G, Münz C, Moormann AM. Poorly cytotoxic terminally differentiated CD56<sup>neg</sup>CD16<sup>pos</sup> NK cells accumulate in
Kenyan children with Burkitt lymphomas. Blood Adv. 2018 May 22;2(10):1101-1114.doi: 10.1182/bloodadvances.2017015404. PMID: 29764843; PMCID: PMC5965049.27: Panea RI, Love CL, Shingleton JR, Reddy A, Bailey JA, Moormann AM, OtienoJA, Ong’echa JM, Oduor CI, Schroeder KMS, Masalu N, Chao NJ, Agajanian M, MajorMB, Fedoriw Y, Richards KL, Rymkiewicz G, Miles RR, Alobeid B, Bhagat G, FlowersCR, Ondrejka SL, Hsi ED, Choi WWL, Au-Yeung RKH, Hartmann W, Lenz G, Meyerson H,Lin YY, Zhuang Y, Luftig MA, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, PalusBC, Seshadri V, Kim SY, Gascoyne RD, Levy S, Mukhopadyay M, Dunson DB, Dave SS.The whole-genome landscape of Burkitt lymphoma subtypes. Blood. 2019 Nov7;134(19):1598-1607. doi:10.1182/blood.2019001880. Erratum in: Blood. 2022 Feb
24;139(8):1256. PMID: 31558468; PMCID: PMC6871305.28: Kinuthia J, Pintye J, Abuna F, Mugwanya KK, Lagat H, Onyango D, Begnel E,Dettinger J, Baeten JM, John-Stewart G; PrEP Implementation for Young Women and Adolescents (PrIYA) programme. Pre-exposure prophylaxis uptake and early continuation among pregnant and post-partum women within maternal and childhealth clinics in Kenya: results from an implementation programme. Lancet HIV.2020 Jan;7(1):e38-e48. doi: 10.1016/S2352-3018(19)30335-2. Epub 2019 Dec 5.
PMID: 31813837.29: Kaymaz Y, Oduor CI, Aydemir O, Luftig MA, Otieno JA, Ong’echa JM, Bailey JA, Moormann AM. Epstein-Barr Virus Genomes Reveal Population Structure and Type 1Association with Endemic Burkitt Lymphoma. J Virol. 2020 Aug17;94(17):e02007-19. doi:10.1128/JVI.02007-19. PMID: 32581102; PMCID:
PMC7431785.30: Forconi CS, Mulama DH, Saikumar Lakshmi P, Foley J, Otieno JA, Kurtis JD,Berg LJ, Ong’echa JM, Münz C, Moormann AM. Interplay between IL-10, IFN-γ,IL-17A and PD-1 Expressing EBNA1-Specific CD4+ and CD8+ T Cell Responses in the Etiologic Pathway to Endemic Burkitt Lymphoma. Cancers (Basel). 2021 Oct 27;13(21):5375. doi: 10.3390/cancers13215375. PMID: 34771539;PMCID: PMC8582526.
31: Saikumar Lakshmi P, Oduor CI, Forconi CS, M’Bana V, Bly C, Gerstein RM,Otieno JA, Ong’echa JM, Münz C, Luftig MA, Brehm MA, Bailey JA, Moormann AM.Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor
variation and testing targeted therapies. Life Sci Alliance. 2023 Mar
6;6(5):e202101355. doi: 10.26508/lsa.202101355. PMID: 36878637; PMCID:
PMC9990458.
Our programmes have been approved by professional bodies governing the teaching & practice of Medicine, Nursing & Clinical Medicine.
These include East African Regional Medical Board, Medical Practitioners & Dentist Board – Kenya, Nursing Council of Kenya and Clinical Officers Council
